Voriconazole

Trade name

Vfend, Voriconazola (Apotex), Voriconazole (MYX), Voriconazole (Wockhardt), Zolfend

Presentation and preparation

Vial size (powder volume)	Fluid to add	Volume to add	Resulting concentration
200 mg (1 mL)	Water for injections	19 mL	10 mg/mL

IV administration

Do not administer the reconstituted solution without further dilution.

Further dilute to 0.5 – 5 mg/mL and give over 1 – 2 hours.

Maximum rate: 3 mg/kg/hour. 

Other routes of administration

IM: Not recommended.

SC: Not recommended.

Compatible IV fluids

Glucose 5%

Glucose 5% and sodium chloride 0.45%

Glucose 5% and sodium chloride 0.9%

Hartmann’s

Sodium chloride 0.9%

Y-site only: 

Plasma-Lyte 148

Potassium chloride 20 mmol/L

Additional information

Potentially hazardous medication: may require special handling precautions, refer to RCH Safe handling of Hazardous Medicines Procedure or relevant local guideline.

Anaphylactoid-type reactions may occur during infusion including fever, flushing, tachycardia, dyspnoea, nausea and rash.

Use with caution in patients predisposed to QT interval prolongation or in patients being administered other medications known to prolong the QT interval. 

Accumulation of injection excipients may occur in patients with renal impairment; oral administration is preferred.

Therapeutic Drug Monitoring may be required: refer to local guidelines.