Valproate
Also known as sodium valproate
Trade name
Epilim, Sodium Valproate (Juno), Sodium Valproate (Wockhardt)
Presentation and preparation
|
Vial size
(powder volume) |
Fluid to add
|
Volume to add
|
Resulting concentration
|
|---|---|---|---|
|
Vial: 400 mg (0.2 mL) |
Water for injections provided | 4 mL | 95 mg/mL |
Vial: Reconstitute with 4 mL of solvent provided to give a 95 mg/mL solution.
Ampoule: 100 mg/mL (volume: 4 mL, 10 mL)
IV administration
Dilute to 50 mg/mL or weaker and give over 3 to 5 minutes.
Intermittent infusion: Dilute to 8 mg/mL or weaker and give over 60 minutes. Maximum rate: 20 mg/minute.
Continuous infusion: Dilute to 8 mg/mL or weaker and give at a rate of 1 to 6 mg/kg/hour.
Haemodialysis: Give at the end of haemodialysis.
Other routes of administration
IM: Not recommended.
SC: Not recommended.
Compatible IV fluids
Glucose 5%
Sodium chloride 0.9%
Valproate 8 mg/mL or weaker:
Glucose 5% and sodium chloride 0.9%
Additional information
Extravasation risk.
Potentially hazardous medication: may require special handling precautions; refer to RCH Safe Handling of Hazardous Medicines Procedure or relevant local guideline.