trimETHOPRIM + Sulfamethoxazole
Also known as co-trimoxazole
Trade name
Bactrim, DBL Sulfamethoxazole and Trimethoprim
Strength
Trimethoprim: 16 mg/mL
Sulfamethoxazole: 80 mg/mL
(volume: 5 mL)
IV administration
Concentrations refer to the trimethoprim component.
Shake diluted solution well to ensure thorough mixing.
Dilute to 0.64 mg/mL and infuse over 1 to 1.5 hours.
Maximum concentration if necessary: Dilute to 1 mg/mL with glucose 5 % only and infuse over 1 hour. Complete infusion as soon as practicable – within 2 hours of dilution.
Intensive care settings, only if necessary: May infuse undiluted via a central line only.
Other routes of administration
IM: Not recommended
SC: Not recommended
Compatible IV fluids
Concentrations refer to the trimethoprim component.
Bactrim: Trimethoprim 0.64 mg/mL stable 6 hours only:
Glucose 5% is the preferred diluent
Glcuose 10%
Sodium chloride
Ringer's
DBL Sulfamethoxazole and trimethoprim: Trimethoprim 0.64 mg/mL:
Glucose 5% is the preferred diluent
Glucose 5 % and sodium chloride 0.45%
Glucose 10%
Hartmann's (8 hours only)
Sodium chloride 0.9%
Trimethoprim 1 mg/mL:
Glucose 5% (1 hour only)
Additional information
Extravasation risk.
Observe closely for anaphylactic and other severe reactions.
Use immediately after dilution.
Check for haze or precipitation during preparation and administration.
Do not use if cloudy or crystallised.
Contains propylene glycol, which can cause CNS depression, hyperosmolality, metabolic acidosis and renal impairment.
Solution should be clear and colourless to slightly yellow.
Protect from light during storage.