Tobramycin

Trade name

Tobra-Day, Tobramycin (DBL), Tobramycin (Pfizer), Tobramycin Viatris

Strength

40 mg/mL (volume: 2 mL)

100 mg/mL (volume: 5 mL)

IV administration

Dilute to 40 mg/mL or weaker and give over 20 minutes to 1 hour. Higher doses are generally administered over 1 hour.

Cystic fibrosis: Dilute to 40 mg/mL or weaker and infuse over 30 minutes.

Other routes of administration

IM: Suitable. Give undiluted by deep IM injection.

SC: Not recommended.

Compatible IV fluids

Glucose 5%

Sodium chloride 0.9% 

Tobramycin 6 mg/mL or weaker:

Glucose 10% 

Tobramycin 1 mg/mL or weaker:

Glucose 5% and sodium chloride 0.9%

Hartmann’s

Ringer’s 

Y-site only and tobramycin 6 mg/mL or weaker:

Potassium chloride 20 mmol/L

Additional information

Observe closely for anaphylactic reactions.

Potentially hazardous medication: may require special handling precautions; refer to RCH Safe Handling of Hazardous Medicines Procedure or relevant local guideline.

IV aminoglycoside antibiotics are inactivated by IV cephalosporins, penicillins and teicoplanin; refer to Glossary and Notes.

Therapeutic Drug Monitoring may be required; refer to local guidelines.

Protect from light during storage.

Tobra-Day and Tobramycin PF (Pfizer):

Refrigerate, do not freeze. 

Tobra-Day:

Solution should be clear to straw-coloured.

Discard any unused vial contents.