Sodium Benzoate

Note: This product is not licensed in Australia at the time of publication. The information in this monograph applies to the specified brand, formulation and strength only.

Trade name

Amzoate

Presentation and preparation

200 mg/mL (volume: 10 mL)

IV administration

RCH only: Refer to Medication Guideline – Sodium Benzoate.

Dilute to 50 mg/mL or weaker and infuse over 1.5 to 2 hours, or by continuous infusion. 

Administer preferably via a central line, or via a large peripheral vein. 

If a loading dose is required, give over 1.5 to 2 hours.

Other routes of administration

IM: Not recommended.

SC: Not recommended.

Compatible IV fluids

Glucose 10% is the preferred diluent.

Glucose 5%

Y-site only:

Glucose 5%

Sodium Chloride 0.9%

Additional information

Use cautiously in neonates due to an increased risk of kernicterus and metabolic acidosis.

Has been co-infused via a Y-site with sodium phenylbutyrate, arginine and carnitine.

Extravasation risk. 

Loading dose may be required; refer to relevant local guideline.

Premedication with ondansetron or similar anti-emetic prior to administration is recommended and may reduce the incidence and intensity of side effects during the infusion. Refer to relevant local guideline.

Therapeutic drug monitoring may be required; refer to local guidelines.