Remdesivir

Trade name

Veklury

Presentation and preparation

Vial size (powder volume)	Fluid to add	Volume to add	Resulting concentration
100 mg (1 mL)	Water for injections	19 mL	5 mg/mL

Reconstitute to 5 mg/mL for IV administration. Shake well for 30 seconds, then allow vial to stand for 2 to 3 minutes. Repeat as necessary until the contents are completely dissolved and solution is clear. Dilute immediately prior to administration.

IV administration

Dilute to required concentration and gently invert the bag or syringe 20 times to mix. Do not shake.

Patients weighing 1.5 kg to less than 40 kg: Dilute reconstituted vial to 1.25 mg/mL.

Patients weighing 40 kg and above: Withdraw and discard volume equal to the remdesivir dose volume from a 100 mL or 250 mL bag of compatible fluid. Add remdesivir dose to the bag. 

Give over 30 minutes to 2 hours.

Maximum concentration if necessary: 2 mg/mL.

Other routes of administration

IM: Not recommended.

SC: Not recommended.

Compatible IV fluids

Sodium chloride 0.9% is the preferred diluent.

Glucose 5%

Additional information

Extravasation risk.

Observe closely for anaphylactic reactions.

Monitor patient for infusion reactions during and at least 1 hour after infusion. Reduce rate of administration if not tolerated.

Contains solubilising excipient sulfobutyl betadex sodium (SBECD). Use with caution in patients with renal dysfunction.

Monitor heart rate during treatment.

Monitor hepatic function, prothrombin time and renal function prior to administration, and during treatment as clinically appropriate.

Use immediately after reconstitution. Discard any unused vial contents.