Piperacillin + Tazobactam
Trade name
Piperacillin/Tazobactam (Kabi), PiperTaz, PipTaz (AFT), Tazopip
Presentation and preparation
|
Vial size
(powder volume) |
Fluid to add
|
Volume to add
|
Resulting concentration
|
|---|---|---|---|
|
Piperacillin 4000 mg Tazobactam 500 mg |
Water for injections
|
17 mL
|
200 mg/mL
|
Concentrations refer to the piperacillin component.
Reconstitute to 200 mg/mL for IV administration. Swirl constantly until dissolved. This may take 10 minutes.
IV administration
Concentrations refer to the piperacillin component.
Further dilute to 80 mg/mL or weaker and infuse over 30 minutes.
Extended infusions may be used in critically ill patients; seek specialist advice.
Haemodialysis: Give at the end of haemodialysis.
Other routes of administration
IM: Not recommended.
SC: Not recommended.
Compatible IV fluids
Glucose 5%
Sodium chloride 0.9%
Y-site only:
Plasma-Lyte 148
Y-site only and piperacillin 40 mg/mL or weaker in glucose 5%:
Potassium chloride 20 mmol/L
Additional information
IV aminoglycoside antibiotics are inactivated by IV cephalosporins, penicillins and teicoplanin; refer to Glossary and Notes.