Phenylephrine

Trade name

Neo-Synephrine, Phenylephrine Baxter, Phenylephrine BNM

Presentation and preparation

Ampoule:

0.1 mg/mL (volume: 5 mL)

10 mg/mL (volume: 1 mL)

Vial:

10 mg/mL (volume: 1 mL)

IV administration

Administer via a large vein or central line.

Neo-Synephrine and Phenylephrine Baxter:

Dilute to 1 mg/mL and give over at least 3 minutes. 

For continuous infusion, dilute to 20 microgram/mL and give preferably via a central line.

Maximum concentration if necessary: 400 microgram/mL.

Phenylephrine BNM: Give undiluted over at least 3 minutes.

In emergencies, any brand can be given undiluted over 20 to 30 seconds.

Other routes of administration

Neo-Synephrine and Phenylephrine Baxter:

IM: Suitable. Give undiluted.

SC: Suitable. Give undiluted.

Phenylephrine BNM:

Not suitable for IM or SC administration.

Compatible IV fluids

Neo-Synephrine and Phenylephrine Baxter:

Glucose 5%

Sodium chloride 0.9%

Y-site only and phenylephrine (Neo-Synephrine and Phenylephrine Baxter) 4 mg/mL or weaker:

Hartmann’s

Ringer’s

Potassium chloride 20 mmol/L

Additional information

Extravasation risk.

Frequent IV catheter site monitoring is recommended.

Use only when facilities for cardiac monitoring and cardio-respiratory resuscitation exist.

Monitor blood pressure and heart rate.

Protect from light during storage.

Neo-Synephrine and Phenylephrine Baxter:

Contains a sulfite preservative.