Neostigmine

Trade name

Neostigmine (Juno)

Strength

2.5 mg/mL (volume: 1 mL)

IV administration

Give undiluted or dilute to a convenient volume and give over at least 1 minute.

Other routes of administration

IM: Suitable. Give undiluted.

SC: Suitable. Give undiluted.

Compatible IV fluids

Glucose 5%

Sodium chloride 0.9%

Y-site only and neostigmine 0.5 mg/mL or weaker:

Plasma-Lyte 148

Potassium chloride 20 mmol/L

Additional information

Use only when facilities for cardiac monitoring and cardio-respiratory resuscitation exist.

Administration may cause bradycardia, hypotension and dysrhythmias, especially with IV use.

Protect from light during storage.

IV administration:

For use in theatre or intensive care settings only.

Ensure atropine or glycopyrronium is available to counteract severe cholinergic reactions.