Naloxone

Trade name

DBL Naloxone, Naloxone (Juno), Naloxone SXP, Narcan

Strength

400 microgram/mL (volume: 1 mL)

IV administration

Give undiluted over 30 seconds. If necessary, may be diluted to 20 to 40 microgram/mL.

For continuous infusion, dilute to 4 microgram/mL.

RCH Standard Concentrations: 4 microgram/mL

Other routes of administration

IV is the preferred route and should be used in emergency situations.

IM: Suitable.

SC: Suitable.

Compatible IV fluids

Glucose 5%

Sodium chloride 0.9%

Y-site only:

Plasma-Lyte 148

Potassium chloride 20 mmol/L

Additional information

Extravasation risk.

If possible, use where facilities for cardiac monitoring and cardio-respiratory resuscitation exist.

Taper the infusion slowly when discontinuing treatment; abrupt discontinuation may cause recurrence of respiratory depression.

Protect from light during storage.

Contact the Poisons Information Centre for more detailed information: 13 11 26.