Solu-Medrol

Also available:

Act-O-Vials:

40 mg/mL (volume: 1 mL)

62.5 mg/mL (volume: 2 mL)

For preparation of Act-O-Vials, follow product information provided in packaging carefully.

IV administration

Doses less than 2 mg/kg AND equal to or less than 250 mg: Give undiluted over at least 5 minutes. 

Doses 2 to 15 mg/kg AND equal to or less than 250 mg: Dilute to 20 mg/mL or weaker and give over at least 15 minutes.

Doses equal to or greater than 15 mg/kg OR greater than 250 mg: Dilute to 20 mg/mL or weaker and give over at least 30 minutes.

Doses equal to or greater than 1000 mg: Dilute to 20 mg/mL or weaker and give over at least 1 hour.

May also be given as a continuous infusion.

Other routes of administration

IM: Suitable. Give undiluted by slow injection into a large muscle. Avoid injection into the deltoid muscle due to high incidence of subcutaneous atrophy.

SC: Not recommended.

Compatible IV fluids

Glucose 5%

Glucose 5% and sodium chloride 0.9%

Glucose 5% and sodium chloride 0.45%

Hartmann’s

Sodium chloride 0.9%

Y-site only and methylprednisolone sodium succinate 125 mg/mL or weaker in glucose 5%, glucose 5% and sodium chloride 0.9%, glucose 5% and sodium chloride 0.45% or sodium chloride 0.9% only:

Potassium chloride 20 mmol/L

Additional information

Do not confuse different salt preparations. Check product selection carefully.

Rapid administration of high doses may cause hypotension, arrhythmias and cardiac arrest.

Use with caution in neonates; contains benzyl alcohol which has been linked with 'gasping syndrome'.

Use immediately after reconstitution.

Discard any unused vial contents.

Protect from light during storage.

Act-O-Vial 40 mg: Contains lactose.