Levetiracetam

Trade name

Levetiracetam (AFT), Levetiracetam (ARX), Levetiracetam (Hospira), Levetiracetam (Medsurge), Levetiracetam (Sandoz)

Strength

100 mg/mL (volume: 5 mL)

IV administration

Dilute to 15 mg/mL or weaker and give over 15 minutes. 

Status epilepticus: Give undiluted or dilute to 50 mg/mL and give over 5 minutes.

Other routes of administration

IM: Not recommended.

SC: May be given as an intermittent or continuous SC infusion in palliative care settings. For continuous SC infusion, dilute with sodium chloride 0.9% or water for injections. 

Compatible IV fluids

Glucose 5%

Sodium chloride 0.9%

Levetiracetam 15 mg/mL or weaker:

Hartmann’s

Additional Information

Taper the infusion slowly when discontinuing treatment; abrupt discontinuation may increase seizure frequency.

Discard any unused vial contents.