Insulin, Neutral
Trade name
Actrapid, Humulin R
Strength
100 units/mL (volume: 3 mL, 10 mL)
IV administration
Dilute to 0.05 – 1 units/mL and give as a continuous infusion via a syringe pump.
Hyperkalaemia: May infuse diluted solution over 5 – 30 minutes.
Refer to RCH Clinical Practice Guideline – Diabetic Ketoacidosis or relevant local guideline for information regarding infusion preparation and rate of administration.
Other routes of administration
IM: Suitable, in an emergency under medical guidance.
SC: Suitable, preferred route. Give as a SC injection into the upper arm, thigh, buttock or abdomen, or as a continuous SC infusion. Actrapid: Do not use in SC insulin infusion pumps due to risk of precipitation.
Refer to RCH Clinical Practice Guideline – Diabetes Mellitus or relevant local guideline for more information.
Compatible IV fluids
Glucose 5%
Glucose 10%
Sodium chloride 0.9%
Y-site only:
Potassium chloride 20 mmol/L
Additional information
Insulin is available in various different formulations; take care when selecting products as medication errors may cause serious harm or be fatal.
Monitor blood glucose levels and electrolytes frequently especially during IV administration.
Insulin adsorbs to glass and plastic containers and giving sets; adjust dose according to clinical response.
Refrigerate, do not freeze.
Protect from light during storage.
When used for SC administration only:
- Vial: Stable for 28 days after opening if stored at room temperature.
- Actrapid cartridge: Stable for 28 days if stored at room temperature.
- Humulin R cartridge: Stable for 21 days if stored at room temperature.