Trade name
Primaxin
Presentation and preparation
|
Vial size
(powder volume) |
Fluid to add
|
Volume to add
|
Resulting concentration
|
|---|---|---|---|
|
Imipenem 500 mg Cilastatin 500 mg |
Sodium chloride 0.9%
|
9.2 mL
|
50 mg/mL
|
Reconstitute with 9.2 mL sodium chloride 0.9% to provide a 50 mg/mL cloudy suspension. Shake well, withdraw dose and dilute immediately. Do not administer without further dilution.
IV administration
Concentrations refer to the imipenem component.
Caution: Complex infusion preparation; do not administer without further dilution.
Further dilute reconstituted solution to 2.5 to 5 mg/mL and shake well to produce a clear solution.
Doses equal to or less than 500 mg: Give over at least 20 minutes.
Doses more than 500 mg: Give over at least 40 minutes.
Haemodialysis: Give at the end of haemodialysis.
Other routes of administration
IM: Not recommended.
SC: Not recommended.
Compatible IV fluids
Glucose 5%
Glucose 5% and sodium chloride 0.9%
Glucose 5% and sodium chloride 0.45%
Glucose 10%
Sodium chloride 0.9%
Y-site only and imipenem 5 mg/mL:
Plasma-Lyte 148
Potassium chloride 20 mmol/L
Additional information
Observe closely for anaphylactic reactions.
Monitor patients for infusion reactions e.g. nausea, and reduce rate of administration if not tolerated.
Solution should be colourless to yellow.