Trade name
Cerezyme
Presentation and preparation
|
Vial size
(powder volume) |
Fluid to add
|
Volume to add
|
Resulting concentration
|
|---|---|---|---|
| 400 units (0.4 mL) |
Water for injections | 10.2 mL | 40 units/mL |
Vials contain a significant amount of overage.
Cerezyme 400 units vials contain 424 units imiglucerase and 0.4 mL powder volume.
Reconstitute to 40 mg/mL for IV administration.
Reconstitute by slowing adding water for injections down the vial wall to avoid foaming. Swirl gently, do not shake.
IV administration
Dilute the dose to 100 to 200 mL with sodium chloride 0.9%. Mix gently, do not shake.
Give over 1 to 2 hours via a 0.2 micron low protein binding filter.
Maximum infusion rate: 1 unit/kg/minute.
Other routes of administration
IM: Not recommended.
SC: Not recommended.
Compatible IV fluids
Sodium chloride 0.9%
Additional information
Observe closely for anaphylactic reactions.
Use only when facilities for cardiac monitoring and cardio-respiratory resuscitation exist.
Refrigerate, do not freeze.
Reconstituted solution should be clear and colourless and may contain thin translucent fibres. Do not use if solution is discoloured or contains opaque particles.
Reconstituted vial is stable for 12 hours.
Diluted solution must be used within 3 hours of preparation.