Trade name
Apresoline
Presentation and preparation
For IV or IM administration:
|
Vial size
(powder volume) |
Fluid to add
|
Volume to add
|
Resulting concentration
|
|---|---|---|---|
| 20 mg (0.06 mL) |
Water for injections | 1 mL | 20 mg/mL |
Reconstitute to 20 mg/mL for IV or IM administration.
20 mg ampoule contains 21.2 mg of hydralazine.
IV administration
Give undiluted or dilute to 0.4 mg/mL and give over at least 5 minutes or by continuous infusion.
Maximum rate: 5 mg/minute.
Other routes of administration
IM: Suitable. Give undiluted.
SC: Not recommended.
Compatible IV fluids
Sodium chloride 0.9%
Hydralazine 0.4 mg/mL or weaker:
Hartmann’s
Ringer’s
Y-site only:
Potassium chloride 20 mmol/L
Y-site only and hydralazine 2 mg/mL or weaker:
Plasma-Lyte 148
Additional information
Extravasation risk.
Monitor blood pressure and heart rate continuously.
Prepare immediately before use.
On dilution, colour changes occur in most infusion solutions within 8 to 12 hours, without affecting potency. Solutions may discolour, often yellow or pink when in contact with metal. Avoid prolonged contact and discoloured solutions should be discarded.
Protect from light during storage.