Hyaluronidase

Trade name

Hyalase

Presentation and preparation

Vial size (powder volume)	Fluid to add	Volume to add	Resulting concentration
1500 units (negligible)	Water for injections	1 mL	1500 units/mL

IV administration

Extravasation management only: May dilute to 150 units/mL and administer into an existing IV line. Management is specific to the extravasated drug; refer to relevant local guideline for detailed information.

Other indications: Never administer intravenously due to lack of clinical effect.

Other routes of administration

IM: Suitable.

SC: Suitable.

Intradermal: Suitable.

Intradermal skin test: Dilute to 150 to 200 units/mL.

Extravasation management: For SC or intradermal administration, dilute to 15 to 150 units/mL. Administer into the leading edge of the extravasation site in multiple small volume injections.

Management is specific to the extravasated drug; refer to relevant local guideline for detailed information.

Other indications: Refer to Product Information or relevant local guideline for detailed administration information.

Compatible IV Fluids

Sodium chloride 0.9%

Hyaluronidase 0.15 units/mL or weaker:

Glucose 5% 

Glucose 5% and sodium chloride 0.9% 

Glucose 5% and sodium chloride 0.45%

Glucose 10% 

Hartmann’s

Ringer’s

Additional information

Observe closely for anaphylactic reactions.

An intradermal skin test is not necessary for extravasation management. For other indications, an intradermal skin test may be performed before the first dose to determine sensitivity; refer to local protocol for more information.

Use immediately after preparation.

Discard any unused contents.