Haem Arginate

Also known as (human) hemin, haematin

Note: This product is not licenced in Australia at the time of publication. The information in this monograph applies to the specified brand, formulation and strength only.

Trade name

Normosang

Presentation and preparation

25 mg/mL (volume: 10 mL)

IV administration

Complex administration; refer to local protocols.

Flush line with sodium chloride 0.9% before and after administration (see below for more detailed information). Dilute dose in 100 mL of sodium chloride 0.9% to give a maximum concentration of 2.5 mg/mL.

Immediately administer over 30 minutes to 1 hour via a central line only, using an infusion set with a filter (e.g. a blood transfusion set) or an amber inline 15-micron filter.

After the infusion, flush the line with 100 mL sodium chloride 0.9% as follows: Give 3 to 4 bolus injections of 10 mL sodium chloride 0.9%, then give the rest by infusion over 10 to 15 minutes.

Glass containers or non-PVC bags and giving sets should be used.

Other routes of administration

IM: Not recommended.

SC: Not recommended.

Compatible IV fluids

Sodium chloride 0.9% 

Additional information

Extravasation risk.

Observe closely for anaphylactic reactions.

Haem arginate is only stable for 1 hour once prepared, ensure central line access is in place prior to preparing the infusion.

Use diluted solution within 1 hour of preparation (including infusion time).

Each 10 mL ampoule of haem arginate contains 1 g of ethanol (96%).

Document brand name and batch number for each dose administered according to local guidelines.

Refrigerate, do not freeze.

Solution is a dark red-brown colour.

Discard any unused vial contents.

Protect from light during storage and administration.