Glyceryl Trinitrate

Also known as nitroglycerin.

Trade name

DBL Glyceryl Trinitrate, Glyceryl Trinitrate Wockhardt

DBL Glyceryl Trinitrate: 5 mg/mL (volume: 10 mL)

Glyceryl Trinitrate Wockhardt: 1 mg/mL (volume: 50 mL)

Dilute to 400 microgram/mL or weaker and give as a continuous infusion.

Maximum concentration if necessary: 1 mg/mL via a central line only.

Non-PVC bags and giving sets should be used.

Many in-line filters adsorb glyceryl trinitrate and should be avoided.

IM: Not recommended.

SC: Not recommended.

Glucose 5%

Sodium chloride 0.9%

Glyceryl Trinitrate 400 microgram/mL or weaker only:

Glucose 5% and sodium chloride 0.9%

Glucose 5% and sodium chloride 0.45%

DBL Glyceryl trinitrate 400 microgram/mL or weaker only:

Hartmann’s

Caution: Y-site medicine and fluid administration may inadvertently change the infusion rate of glyceryl trinitrate.

DBL Glyceryl Trinitrate Y-site only and glyceryl trinitrate 600 microgram/mL or weaker only:

Plasma-Lyte 148

DBL Glyceryl Trinitrate Y-site only:

Potassium chloride 20 mmol/L

Use only when facilities for cardiac monitoring and cardio-respiratory resuscitation exist.

Tolerance may develop within 24 – 48 hours of continuous use; a daily nitrate-free interval may be required.

Taper the infusion slowly when discontinuing prolonged treatment; abrupt discontinuation may cause a withdrawal reaction.

Use with caution in neonates; contains propylene glycol, which can cause CNS depression, hyperosmolality, metabolic acidosis and renal impairment.

DBL glyceryl trinitrate contains alcohol: Alcohol intoxication has occurred using high dose intravenous infusions.

Protect from light during storage.