Flumazenil

Anexate, Flumazenil-Baxter, Flumazenil (Kabi)

Strength

100 microgram/mL (volume: 5 mL, 10 mL)

IV administration

Give undiluted over 15 seconds via a large vein, or dilute to a convenient volume and give as a continuous infusion.

For IV injection:

Maximum rate: 200 microgram/minute

For IV infusion:

Maximum rate: 400 microgram/hour

Other routes of administration

IM: Not recommended.

SC: Not recommended.

Compatible IV fluids

Glucose 5%

Sodium chloride 0.9%

Hartmann’s

Additional information

Extravasation risk.

Observe closely for anaphylactic reactions.

Monitor patient for recurrence of sedation and respiratory depression for at least 2 hours after administration of the last dose.

Monitor for 4 hours with long-acting or large doses of benzodiazepines, and for patients with hepatic impairment.

Benzodiazepine reversal may precipitate seizures: use cautiously in patients who have received prolonged benzodiazepine therapy or those with seizure history, hepatic impairment, head injury or mixed-drug overdose.

Protect from light during storage.

Contact the Poisons Information Centre for more detailed information: 13 11 26.