flucLOXACILLIN

Also known as floxacillin

Trade name

Flubiclox, Flucil, Flucloxacillin (Baxter), Flucloxacillin (Kabi)

Flucloxacillin WABO

Note: This product is not licenced in Australia at the time of publication. The information in this monograph applies to the specified brand, formulation and strength only.

Presentation and preparation

For IV administration:

Vial size (powder volume)	Fluid to add	Volume to add	Resulting concentration
500 mg (0.4 mL)	Water for injections	9.6 mL	50 mg/mL
1 g (0.7 mL)	Water for injections	19.3 mL	50 mg/mL
2 g (1.5 mL)	Water for injections	38.5 mL	50 mg/mL
4 g (2.8 mL)	Water for injections	77.2 mL	50 mg/mL

Reconstitute to 50 mg/mL for IV administration.

For IM administration:

Vial size (powder volume)	Fluid to add	Volume to add	Resulting concentration
500 mg (0.4 mL)	Water for injections	2 mL	208 mg/mL
1 g (0.7 mL)	Water for injections	2.5 mL	312.5 mg/mL

Reconstitute to 208 mg/mL or 312.5 mg/mL for IM administration.

IV administration

Further dilute the reconstituted solution to a convenient volume and infuse over at least 30 minutes.

If necessary, may be given undiluted or as slow injection over 3 to 4 minutes; however, this can cause significant pain and/or phlebitis and may result in loss of the IV line.

Other routes of administration

IV is the preferred route in neonates and infants.

IM: Suitable.

SC: Not recommended.

Compatible IV fluids

Glucose 5%

Glucose 5% and sodium chloride 0.9%

Hartmann’s

Sodium chloride 0.9%

Y-site only and with sodium chloride 0.9%:

Potassium chloride 20 mmol/L

Y-site only and flucloxacillin 40 mg/mL or weaker: 

Plasma-Lyte 148

Additional information

Extravasation risk.

IV aminoglycoside antibiotics are inactivated by IV cephalosporins, penicillins and teicoplanin; refer to Glossary and Notes. 

Rapid administration may result in seizures.

Use immediately after reconstitution. Discard any unused vial contents.

Protect from light during storage.

Flucloxacillin WABO: Solution should be clear, colourless or pale yellow.