Etanercept

Trade name

Brenzys*, Enbrel

*Brenzys is a biosimilar product of Enbrel

Presentation and preparation

Vial size (powder volume)	Fluid to add	Volume to add	Resulting concentration
25 mg (negligible)	Water for injections provided	1 mL	25 mg/mL

Attach the vial adaptor to the syringe and reconstitute vial with 1 mL water for injections provided, injecting slowly into vial to reduce foaming. Some foaming will occur; this is normal. Swirl gently, do not shake. Stand for 10 minutes until the solution becomes clear. Draw up the dose in the syringe, discard the vial adaptor, and replace with needle for injection.

Also available:

Auto-injector (injection pen): 

50 mg/mL (volume: 1 mL)

Dose-dispenser cartridge:

50 mg/mL (volume: 0.5 mL, 1mL)

Prefilled syringe: 

50 mg/mL (volume: 1 mL)

For auto-injector, dose-dispenser cartridge and prefilled syringe: Remove needle cover immediately prior to administration.

All products: Remove from refrigerator, allow to come to room temperature for 15 to 30 minutes (minimum 30 minutes for auto-injector) before injecting. Do not shake.

IV administration

Not recommended.

Other routes of administration

IM: Not recommended.

SC: Suitable. Maximum volume per site is 1 mL. Inject into the thigh, abdomen or upper arm, at least 3 cm from a previously used site. Do not administer into areas where the skin is tender, bruised, red or hard.

Additional information

Observe closely for anaphylactic reactions.

Refrigerate, do not freeze.

Protect from light during storage.

Brenzys: 

Auto-injector and prefilled syringe only: Solution should be clear to opalescent and colourless or pale yellow. 

Enbrel: 

All products: Solution should be colourless to slightly yellow or pale brown, and clear to slightly opalescent. Closure of diluent syringe (vial presentation), needle covers and caps contain natural rubber latex.

Vial only: Reconstituted vial is stable for 6 hours if refrigerated.