Epoprostenol – Veletri
Also known as prostacyclin, PGI2, prostaglandin I2, PGX
Trade name
Veletri
Presentation and preparation
|
Vial size
(powder volume) |
Fluid to add
|
Volume to add
|
Resulting concentration
|
|---|---|---|---|
| 500 microgram (negligible) |
Water for injections OR Sodium chloride 0.9% | 5 mL | 100 microgram/mL |
| 1500 mg (negligible) |
Water for injections OR Sodium chloride 0.9% | 5 mL | 300 microgram/mL |
Reconstitute to 100 microgram/mL (500 microgram vial) or 300 microgram/mL (1500 microgram vial) for IV administration.
Immediately dilute with the same diluent used to reconstitute Veletri.
IV administration
Do not administer without further dilution.
Dilute reconstituted solution to 3 microgram/mL or stronger.
Minimum concentration if necessary for small doses: 0.5 microgram/mL.
Veletri is administered only as a continuous infusion, preferably via a central line.
Veletri solutions must be filtered, using an appropriate 0.22 micron in-line filter.
Infusion rates are expressed in nanogram/kg/minute.
1 microgram = 1000 nanograms
Other routes of administration
IM: Contraindicated.
SC: Contraindicated.
Compatible IV fluids
Sodium chloride 0.9%
Additional information
Extravasation risk.
Monitor blood pressure and pulse rate.
Avoid even brief interruptions to infusion delivery and never flush or bolus the line as this can lead to rapid clinical deterioration.
Taper the infusion slowly when discontinuing treatment; abrupt discontinuation may cause rebound hypertension.
Discard unused vial contents.
Protect from light during storage and from direct sunlight during administration.