Digoxin-specific Antibody Fragment F(Ab)

Also known as digoxin-specific antibody, digoxin immune Fab

Trade name

DigiFab

Presentation and preparation

Vial size
(powder volume)
Fluid to add
Volume to add
Resulting concentration
40 mg
(negligible)
Water for injections 4 mL  10 mg/mL

Reconstitute to 10 mg/mL for IV administration. 

Swirl gently to dissolve. Do not shake.

IV administration

Give undiluted, or for small doses, dilute to 1 mg/mL and give over 30 minutes.

If cardiac arrest is imminent, give via rapid injection.

Other routes of administration

IM: Not recommended.

SC: Not recommended.

Compatible IV fluids

Sodium chloride 0.9% (4 hours if refrigerated)

Additional information

Rapid administration may cause infusion-related reactions. Monitor patient for infusion reactions and reduce rate of administration if not tolerated. 

Reconstituted solution should be clear and colourless to slightly opalescent or pale yellow.

Prepared infusions should be used immediately.

Refrigerate, do not freeze.

Discard any unused vial contents.

Contact the Poisons Information Centre for more detailed information: 13 11 26.

 


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