Digoxin

Trade name

Lanoxin Infants

Lanoxin Adult

Lanoxin Infants:

25 microgram/mL (volume: 2 mL)

Lanoxin Adult:

250 microgram/mL (volume: 2 mL)

Lanoxin Infants (preferred): Give undiluted or dilute to 5 microgram/mL and give over at least 5 minutes.

Lanoxin Adult: Dilute to 62.5 microgram/mL or weaker and give over at least 5 minutes.

To avoid inadvertent overdose when diluting digoxin:

Draw up digoxin in one syringe and add it to a second syringe containing diluent.
Do not flush the drawing up syringe.
Do not flush the syringe after administration.

IM: Not recommended as tissue damage and severe pain may occur.

Lanoxin Infants only: If necessary, give undiluted by deep IM injection and massage site after administration.

SC: Not recommended.

Glucose 5%

Sodium chloride 0.9%

Digoxin 2.5 microgram/mL or weaker:

Glucose 5% and sodium chloride 0.45%

Hartmann’s

Y-site only:

Plasma-Lyte 148

Potassium chloride 20 mmol/L

Extravasation risk.

Use only when facilities for cardiac monitoring and cardio-respiratory resuscitation exist.

Rapid administration may cause systemic and coronary arteriolar vasoconstriction.

Therapeutic Drug Monitoring required; refer to local guidelines. Levels should be taken at least 6 hours after the dose is given.

Contains propylene glycol, which can cause CNS depression, hyperosmolality, metabolic acidosis and renal impairment.

Contains ethanol which can cause drowsiness, behavioural changes, impaired concentration, ataxia, hypothermia and hypoglycaemia.

Protect from light during storage.