Denosumab

Trade name

Prolia, Xgeva

Presentation and preparation

Prolia prefilled syringe:

60 mg/mL (volume: 1 mL)

Xgeva vial:

70.6 mg/mL (volume: 1.7 mL)

IV administration

Never administer intravenously.

Other routes of administration

IM: Not recommended.

SC: Recommended. Give undiluted by slow SC injection into the upper thigh, abdomen or upper arm. Do not rub injection site.

Prolia prefilled syringe: Refer to product information or local guidelines for detailed administration instructions.

Xgeva vial: A 27 or 25 gauge needle is recommended for administration.

Additional information

Observe closely for anaphylactic reactions.

Do not shake.

Refrigerate, do not freeze.

Remove from refrigerator, allow to come to room temperature for 15 to 30 minutes before injecting.

Solution should be clear and colourless to slightly yellow, may contain trace amounts of translucent to white proteinaceous particles, do not use if cloudy.

Discard any unused vial or syringe contents.

Protect from light during storage.