Defibrotide
Trade name
Defitelio
Strength
80 mg/mL (volume: 2.5 mL)
IV administration
Dilute to between 4 and 20 mg/mL and infuse over 2 hours via a 0.2 micron in-line filter.
Mix gently, do not shake.
Other routes of administration
IM: Not recommended.
SC: Not recommended.
Compatible IV fluids
Glucose 5%
Sodium chloride 0.9%
Additional information
Potentially hazardous medication: may require special handling precautions; refer to RCH Safe Handling of Hazardous Medicines Procedure or relevant local guideline.
Observe closely for anaphylactic reactions, especially in patients with previous exposure to defibrotide.
Monitor the patient for signs of bleeding.
Solution should be clear and light yellow to brown.
Discard any unused vial contents.