cefTAZIDIME + Avibactam

Trade name

Zavicefta

Presentation and preparation

Vial size (powder volume)	Fluid to add	Volume to add	Resulting concentration
Ceftazidime  2000 mg Avibactam  500 mg (2 mL)	Water for injections	10 mL	Ceftazidime  167 mg/mL Avibactam  42 mg/mL

Concentrations refer to the ceftazidime component.

Reconstitute to 167 mg/mL for IV administration. Shake gently until completely dissolved. Reconstitution can take up to 4 minutes. Once dissolved, insert an airway needle to relieve pressure and avoid product loss. The total time interval between starting reconstitution and completing preparation of the intravenous infusion should not exceed 30 minutes.

IV administration

Concentrations refer to the ceftazidime component.

Dilute reconstituted solution to 8 to 40 mg/mL and infuse over 2 hours.

Haemodialysis: Give at the end of haemodialysis.

Other routes of administration

IM: Not recommended.

SC: Not recommended.

Compatible IV fluids

Glucose 5%

Hartmann’s

Sodium chloride 0.9%

Additional information

IV aminoglycoside antibiotics are inactivated by IV cephalosporins, penicillins and teicoplanin; refer to Glossary and Notes.

Solution should be clear and colourless to yellow.

Use immediately after reconstitution.

Protect from light during storage.