Trade name
Ceftazidime-AFT, Ceftazidime (Juno), Ceftazidime (Kabi), Ceftazidine (Viatris)
Presentation and preparation
For IV administration:
|
Vial size
(powder volume) |
Fluid to add
|
Volume to add
|
Resulting concentration
|
|---|---|---|---|
| 1 g (0.9 mL) |
Water for injections | 5 mL | 170 mg/mL |
| 2 g (1.8 mL) |
Water for injections | 10 mL | 170 mg/mL |
Reconstitute to 170 mg/mL for IV administration. After reconstitution, gases accumulate and should be expelled from the syringe and/or vented from the vial.
For IM administration:
|
Vial size
(powder volume) |
Fluid to add
|
Volume to add
|
Resulting concentration
|
|---|---|---|---|
| 1 g (0.9 mL) |
Water for injections OR Lidocaine 0.5%* or 1% | 3 mL | 260 mg/mL |
Reconstitute to 260 mg/mL for IM administration. After reconstitution, gases accumulate and should be expelled from the syringe and/or vented from the vial.
*Dilute lidocaine 1% with an equal quantity of water or sodium chloride 0.9% to make a 0.5% solution.
IV administration
Give reconstituted solution undiluted over at least 3 minutes or further dilute to 40 mg/mL or weaker and give over 15 to 30 minutes.
Can be given as a continuous infusion. Refer to local guidelines.
Haemodialysis: Give at the end of haemodialysis.
CoPAT Administration:
Stable at 30 mg/mL or weaker for 24 hours at 25°C or below. Stability data is limited for temperatures at 25°C and above; refer to Glossary and Notes for storage advice.
Other routes of administration
IV is the preferred route in neonates.
IM: Suitable. Give undiluted by deep IM injection into a large muscle mass.
SC: Not recommended.
Compatible IV fluids
Glucose 5%
Glucose 5% and sodium chloride 0.9%
Glucose 5% and sodium chloride 0.45%
Glucose 10%
Hartmann’s
Ringer’s
Sodium chloride 0.9%
Y-site only and ceftazidime 100 mg/mL or weaker:
Plasma-Lyte 148
Additional information
IV aminoglycoside antibiotics are inactivated by IV cephalosporins, penicillins and teicoplanin; refer to Glossary and Notes.
Ceftazidime (Kabi) and Ceftazidime-AFT: Reconstituted vial stable for 12 hours when refrigerated.
Reconstituted solution should be clear, colourless or slightly yellow to amber.
Protect from light during storage.