cefOXITIN
Trade name
Cefoxitin (Juno)
Presentation and preparation
For IV administration:
|
Vial size
(powder volume) |
Fluid to add
|
Volume to add
|
Resulting concentration
|
|---|---|---|---|
| 1 g (0.5 mL) |
Water for injections | 9.5 mL | 100 mg/mL |
| 2 g (1.1 mL) |
Water for injections | 18.9 mL | 100 mg/mL |
Reconstitute to 100 mg/mL for IV administration.
For IM administration:
|
Vial size
(powder volume) |
Fluid to add
|
Volume to add
|
Resulting concentration
|
|---|---|---|---|
| 1 g (0.5 mL) |
Water for injections OR Lidocaine 0.5%* or 1% | 2 mL | 400 mg/mL |
| 2 g (1.1 mL) |
Water for injections OR Lidocaine 0.5%* or 1% | 3.9 mL | 400 mg/mL |
Reconstitute to 400 mg/mL for IM administration.
Pain at the site of injection is often severe when cefoxitin IM is reconstituted using water for injections.
*Dilute lidocaine 1% with an equal quantity of water or sodium chloride 0.9% to make a 0.5% solution.
IV administration
Give reconstituted solution over at least 3 minutes or further dilute to 40 mg/mL or weaker and infuse over 10 to 60 minutes.
Maximum concentration for peripheral administration: 125 mg/mL.
Can be given as a continuous infusion.
Other routes of administration
IM: Suitable. Give undiluted by deep IM injection into a large muscle mass.
SC: Not recommended.
Compatible IV fluids
Glucose 5%
Glucose 5% and sodium chloride 0.9%
Glucose 5% and sodium chloride 0.45%
Glucose 10%
Hartmann's
Sodium chloride 0.9%
Y-site only and cefoxitin 20 mg/mL or weaker:
Plasma-Lyte 148
Y-site only:
Potassium chloride 20 mmol/L
Additional information
IV aminoglycoside antibiotics are inactivated by IV cephalosporins, penicillins and teicoplanin; refer to Glossary and Notes.
Solution is clear, colourless to pale yellow in colour. Solution may darken upon storage but can still be used.
Protect from light during storage.