cefEPIME
Trade name
Cefepime (AFT), Cefepime (Kabi)
Presentation and preparation
For IV administration:
|
Vial size
(powder volume) |
Fluid to add
|
Volume to add
|
Resulting concentration
|
|---|---|---|---|
| 1 g (1.3 mL) |
Sodium chloride 0.9% OR Glucose 5% | 8.7 mL | 100 mg/mL |
| 2 g (2.6 mL) |
Sodium chloride 0.9% OR Glucose 5% | 17.4 mL | 100 mg/mL |
Reconstitute to 100 mg/mL for IV administration.
For IM administration:
|
Vial size
(powder volume) |
Fluid to add
|
Volume to add
|
Resulting concentration
|
|---|---|---|---|
| 1 g (1.3 mL) |
Water for injections OR Lidocaine 1% | 3 mL | 230 mg/mL |
| 2 g (2.6 mL) |
Water for injections OR Lidocaine 1% | 6.1 mL | 230 mg/mL |
Reconstitute to 230 mg/mL for IM administration.
IV administration
Dilute reconstituted solution to 40 mg/mL or weaker and infuse over 30 minutes.
In severe or life-threatening infections, may be used undiluted (100 mg/mL). Give by slow IV injection over at least 3 minutes.
Other routes of administration
IV is the preferred route.
IM: Suitable. Give reconstituted solution by deep IM injection into a large muscle mass.
SC: Not recommended.
Compatible IV fluids
Glucose 5%
Sodium chloride 0.9%
Cefepime 40 mg/mL or weaker
Glucose 5% and sodium chloride 0.9%
Glucose 10%
Hartmann's
Y-site only and cefepime 20 mg/mL or weaker:
Potassium chloride 20 mmol/L
Additional information
IV aminoglycoside antibiotics are inactivated by IV cephalosporins, penicillins and teicoplanin; refer to Glossary and Notes.
Reconstituted solution should be clear and colourless or slightly yellow to amber. Reconstituted solution may darken on storage without affecting potency.
Protect from light during storage.