Trade name
Cefazolin (AFT), Cephazolin (Viatris), Kefzol
Presentation and preparation
For IV administration:
|
Vial size
(powder volume) |
Fluid to add
|
Volume to add
|
Resulting concentration
|
|---|---|---|---|
| 500 mg (0.2 mL) |
Water for injections | 4.8 mL | 100 mg/mL |
| 1 g (0.5 mL) |
Water for injections | 9.5 mL | 100 mg/mL |
| 2 g (1 mL) |
Water for injections | 19 mL | 100 mg/mL |
Reconstitute to 100 mg/mL for IV administration. Shake well until dissolved.
For IM administration:
|
Vial size
(powder volume) |
Fluid to add
|
Volume to add
|
Resulting concentration
|
|---|---|---|---|
| 500 mg (0.2 mL) |
Water for injections OR Lidocaine 0.5%* | 2 mL | 225 mg/mL |
| 1 g (0.5 mL) |
Water for injections OR Lidocaine 0.5%* | 2.5 mL | 333 mg/mL |
| 2 g (1 mL) |
Water for injections OR Lidocaine 0.5%* | 5 mL | 333 mg/mL |
Reconstitute to 225 mg/mL or 333 mg/mL for IM administration. Shake well and warm in hands to aid dissolution. Use immediately after reconstitution.
*Dilute lidocaine 1% with an equal quantity of water or sodium chloride 0.9% to make a 0.5% solution.
IV administration
Give undiluted over 3 to 5 minutes or further dilute to 20 mg/mL or weaker and give over 10 to 60 minutes.
Doses greater than 30 mg/kg: Give over at least 5 minutes.
Can be given as a continuous infusion.
Maximum concentration if necessary: 138 mg/mL and give over at least 3 minutes.
CoPAT Administration:
Stable at 25 mg/mL for 24 hours at 31°C.
Other routes of administration
IM: Suitable. Give undiluted by deep IM injection into a large muscle mass.
SC: Not recommended.
Compatible IV fluids
Sodium chloride 0.9%
Cefazolin 40 mg/mL or weaker:
Glucose 5%
Cefazolin 20 mg/mL or weaker:
Glucose 5% and sodium chloride 0.9%
Glucose 5% and sodium chloride 0.45%
Glucose 10%
Hartmann’s
Ringer’s
Y-site only and cefazolin 138 mg/mL or weaker:
Glucose 5%
Glucose 5% and sodium chloride 0.9%
Glucose 5% and sodium chloride 0.45%
Glucose 10%
Hartmann’s
Ringer’s
Potassium chloride 20 mmol/L
Y-site only and cefazolin 40 mg/mL or weaker:
Plasma-Lyte 148
Additional information
IV aminoglycoside antibiotics are inactivated by IV cephalosporins, penicillins and teicoplanin; refer to Glossary and Notes.
Reconstituted solutions should be clear and colourless or light/pale yellow to yellow.
Protect from light during storage.