Caspofungin

Trade name

Caspofungin AN

Presentation and preparation

Vial size (powder volume)	Fluid to add	Volume to add	Resulting concentration
50 mg (3 mL)	Water for injections	10.5 mL	5.2 mg/mL
70 mg (4.2 mL)	Water for injections	10.5 mL	7.2 mg/mL

Vials contain a significant amount of overage; 50 mg vials contain 3 mL of powder volume and 70 mg vials contain 4.2 mL of powder volume.

Allow vial to come to room temperature before reconstitution. Reconstitute with 10.5 mL to provide a 5.2 mg/mL (50 mg vial) or 7.2 mg/mL (70 mg vial) solution. Gently rotate the vial until a clear solution is obtained. Do not shake. Further dilute immediately for infusion.

IV administration

Do not administer without further dilution. Dilute to 0.5 mg/mL or weaker and infuse over 1 hour.

Other routes of administration

IM: Not recommended.

SC: Not recommended.

Compatible IV fluids

Hartmann’s

Sodium chloride 0.9% 

Y-site only:

Plasma-Lyte 148

Potassium chloride 20 mmol/L

Additional information

Reconstituted vial is stable for 1 hour. 

Discard any unused vial contents.

Refrigerate, do not freeze.