Aztreonam
Trade name
Azactam
Presentation and preparation
For IV administration:
|
Vial size
(powder volume) |
Fluid to add
|
Volume to add
|
Resulting concentration
|
|---|---|---|---|
| 1 g (1.2 mL) |
Water for injections | 9.1 mL | 100 mg/mL |
Reconstitute to 100 mg/mL for IV administration.
Shake vial vigorously until powder is dissolved. There is approximately 0.3 mL overage in the vial. Reconstituted solution must be used or diluted further immediately.
A slight pink tint may develop on standing without affecting potency.
For IM administration:
|
Vial size
(powder volume) |
Fluid to add
|
Volume to add
|
Resulting concentration
|
|---|---|---|---|
| 1 g (1.2 mL) |
Water for injections | 2.6 mL | 270 mg/mL |
Reconstitute to 270 mg/mL or weaker for IM administration.
Shake vigorously until powder is dissolved. A slight pink tint may develop on standing without affecting potency.
IV administration
Give reconstituted solution over 3 – 5 minutes.
Maximum concentration if necessary: 149 mg/mL.
Intermittent infusion: dilute to 20 mg/mL or weaker give over 20 – 60 minutes.
Other routes of administration
IV administration is the preferred route for doses greater than 1 g.
IM: Suitable. Give reconstituted solution by deep IM injection into a large muscle mass.
SC: Not recommended.
Compatible IV fluids
Sodium chloride 0.9%
Aztreonam 20 mg/mL or weaker:
Glucose 5%
Glucose 5% and sodium chloride 0.45%
Glucose 5% and sodium chloride 0.9%
Glucose 10%
Hartmann’s
Ringer’s
Y-site only and aztreonam 20 mg/mL or weaker:
Potassium chloride 20 mmol/L
Additional information
Reconstituted solution should be clear and colourless to pale yellow or slight pink.
IV: reconstituted solution should be used immediately. Discard any unused vial contents.
IM: reconstituted solution is stable for 48 hours.