Argipressin (vasopressin)

Argipressin Medsurge, Pitressin

Cpressin-P

Note: This product is not licenced in Australia at the time of publication. The information in this monograph applies to the specified brand, formulation and strength only.

Strength

20 units/mL (volume: 1 mL)

IV administration

Dilute to 0.1 to 1 unit/mL and give as a continuous infusion.

Infuse preferably via central line using a syringe or infusion pump with DERS.

RCH Standard Concentrations:

Neonatal:

5 units/25 mL (0.2 units/mL)

10 units/25 mL (0.4 units/mL)

All other paediatric ages:

10 units/50 mL (0.2 units/mL)

20 units/50 mL (0.4 units/mL)

40 units/40 mL (1 unit/mL)

50 units/50 mL (1 unit/mL)

Other routes of administration

IM: Suitable. Give undiluted.

SC: Suitable. Give undiluted.

Compatible IV fluids

Glucose 5% (18 hours only) 

Sodium chloride 0.9% (18 hours only)

Argipressin 0.4 units/mL or weaker only:

Sodium chloride 0.9%

Caution: Y-site medicine and fluid administration may inadvertently change the infusion rate of argipressin.

Y-site only:

Glucose 10%

Hartmann’s

Ringer’s

Potassium chloride 20 mmol/L

Additional information

Extravasation risk.

Taper the infusion slowly when discontinuing treatment; abrupt discontinuation may cause hypotension. Refer to local guidelines.

Continuous cardiac monitoring required.

Monitor fluid balance, urine output and electrolytes.

Argipressin Medsurge, Pitressin: Refrigerate, do not freeze.

Argipressin Medsurge: Discard any unused vial content.

Protect from light during storage.