Antithymocyte Globulin ‒ Rabbit (Grafalon)

Also known as Rabbit-ATG, rATG.

See separate monograph for Antithymocyte Globulin – Rabbit (Thymoglobuline)

Note: This product is not licenced in Australia at the time of publication. The information in this monograph applies to the specified brand, formulation and strength only.

Trade name

Grafalon

Strength

20 mg/mL (volume: 5 mL, 10 mL)

IV administration

Dilute to 2.86 mg/mL and infuse over at least 4 hours, preferably via a central line or large peripheral high flow vein.

First dose should be administered at a reduced infusion rate for the first 30 minutes. If no reaction, infusion rate may be increased.

Other routes of administration

IM: Not recommended.

SC: Not recommended.

Compatible IV fluids

Sodium chloride 0.9%

Additional information

Observe closely for anaphylactic reactions.

Premedication with corticosteroids, antipyretic agents and/or antihistamine 1 hour prior to the infusion is recommended and may reduce the incidence and intensity of side effects during the infusion.

Monitor patient for infusion reactions and reduce rate of administration if not tolerated.

Refrigerate, do not freeze.

Protect from light during storage.

Solution is clear to slightly opalescent and colourless to pale yellow.