Amphotericin B, Liposomal
Caution: Multiple forms of amphotericin B exist. Check product selection carefully.
Trade name
AmBisome
Presentation and preparation
|
Vial size
(powder volume) |
Fluid to add
|
Volume to add
|
Resulting concentration
|
|---|---|---|---|
| 50 mg (0.5 mL) |
Water for injections | 12 mL | 4 mg/mL |
IV administration
Complex infusion preparation.
Do not administer without further dilution.
Draw up desired dose into a syringe then inject the dose through the 5 micron filter provided into glucose 5% for dilution to achieve a final concentration between 0.2 mg/ml and 2 mg/ml.
Where multiple vials are required, use one 5 micron filter per vial during preparation.
In-line filters of 1 micron or greater may be used for administration.
Infuse over 2 hours.
If doses infused over 2 hours are tolerated, then infusion time may be reduced to 1 hour, provided there has not been more than 1 week since the last tolerated infusion.
If doses infused over 1 hour are tolerated, then infusion may be given over 30 minutes if necessary, provided there has been not been more than 1 week since the last rapid infusion.
Other routes of administration
IM: Not recommended.
SC: Not recommended.
Compatible IV fluids
Glucose 5%
Glucose 10%
Additional information
Observe closely for anaphylactic reactions.
Flush line well with glucose 5% before and after administration, or administer through a separate line.
Non-anaphylactic infusion-related reactions may occur. Some patients may benefit from receiving premedication.
Reconstituted solution should appear translucent and yellow.