Amoxicillin + Clavulanic Acid

Trade name

Amoxiclav Juno, Curam

Presentation and preparation

Vial size (powder volume)	Fluid to add	Volume to add	Resulting concentration
Amoxicillin 500 mg Clavulanic acid 100 mg (0.5 mL)	Water for injections	9.5 mL	50 mg/mL
Amoxicillin 1000 mg Clavulanic acid 200 mg (0.9 mL)	Water for injections	19.1 mL	50 mg/mL
Amoxicillin 2000 mg Clavulanic acid 200 mg (0.9 mL)	Water for injections	19.1 mL	100 mg/mL*

 Use immediately after reconstitution (stable for 20 minutes).

*2000 mg vial: Immediately dilute further before administration

Not all products are interchangeable.

Selecting a product with the appropriate amoxicillin to clavulanic acid ratio is important to prevent under or overdosing of the clavulanic acid component. Refer to relevant local guidelines.

For doses of amoxicillin component greater than 1000 mg:

Prepare the dose required using preparations containing Amoxicillin 2000 mg + Clavulanic Acid 200 mg

IV administration

Concentrations refer to the amoxicillin component.

Dilute reconstituted solution to 50 mg/mL and give over 3 minutes, or dilute to 20 mg/mL or weaker and infuse over 30 minutes.

Neonates and infants less than 3 months:

Dilute to 20 mg/ml or weaker and infuse over 30 minutes.

Other routes of administration

IM: Not recommended.

SC: Not recommended.

Compatible IV fluids

Prepared infusions should be used immediately.

Sodium chloride 0.9% (4 hours only)

Hartmann’s (3 hours only)

Ringer’s (3 hours only)

Additional information

IV aminoglycoside antibiotics are inactivated by iv cephalosporins, penicillins and teicoplanin; refer to Glossary and Notes.

Ensure adequate hydration.

Use immediately after reconstitution (stable for 20 minutes). Discard any unused vial contents.

Reconstituted solution should be clear and colourless or slightly yellow. A transient pink colour may appear.

Protect from light during storage.