amiODAROne

Trade name

Amiodarone GH, Amiodarone Juno, Cordarone X

Strength

50 mg/mL (volume: 3 mL)

IV administration

Amiodarone must be infused at a controlled rate using a syringe driver or infusion pump via a 0.2 micron low protein binding in-line filter.

Dilute to 1 to 6 mg/mL and give loading dose over 20 minutes to 2 hours followed by a continuous infusion. Refer to local protocols or guidelines.

For concentrations greater than 2 mg/mL, give via a central line only.

In emergencies, may be given undiluted over at least 3 minutes during resuscitation of patients with pulseless VT or VF. Follow immediately with glucose 5% flush.

Non-PVC bags and giving sets should be used.

Infusions should be completed within 12 hours of preparation.

RCH Standard Concentrations:

Central line access:

0 to < 10 kg: 150 mg/50 mL (3 mg/mL)

10 to < 40 kg: 300 mg/50 mL (6 mg/mL)

40 kg+: 600 mg/100 mL (6 mg/mL)

Peripheral line access:

0 to < 40 kg: 100 mg/50 mL (2 mg/mL)

40 kg+: 200 mg/100 mL (2 mg/mL)

Other routes of administration

IM: Not recommended.

SC: Not recommended.

Compatible IV fluids

Glucose 5%

Additional information

Extravasation risk.

Use only when facilities for cardiac monitoring and cardio-respiratory resuscitation exist.

Use with caution in neonates; contains benzyl alcohol which has been linked with ‘gasping syndrome’.

Use with caution in patients predisposed to QT interval prolongation or in patients being administered other medications known to prolong the QT interval.

Solution should be clear to slightly yellow.

Protect from light during storage.