amiNOPHYLLine

DBL Aminophylline

Strength

25 mg/mL (volume: 10 mL)

IV administration

Dilute to 1 mg/mL. 

Loading dose: infuse over 30 – 60 minutes.

Subsequent doses: infuse over at least 30 minutes or by continuous infusion.

Maximum concentration if necessary: 25 mg/mL preferably via a central line.

Rapid administration may result in toxic serum concentrations, seizures and circulatory failure.

Other routes of administration

IM: Not recommended.

SC: Not recommended.

Compatible IV fluids

Aminophylline 20 mg/mL or weaker:

Sodium chloride 0.9%

Aminophylline 10 mg/mL or weaker:

Glucose 5%

Glucose 5% and sodium chloride 0.9%

Glucose 10%

Hartmann’s

Y-site only and aminophylline 25 mg/mL or weaker:

Potassium chloride 20 mmol/L

Additional information

Extravasation risk: pH ~ 8.8 - 10.

Use only when facilities for cardiac monitoring and cardio-respiratory resuscitation exist.

May lower seizure threshold; use with cautiously in patients with seizure history.

Therapeutic Drug Monitoring may be required; refer to local guidelines.

Protect from light during storage.

Discard any unused ampoule contents.