Trade name
Neupedix, Prostin VR
Strength
500 microgram/mL (volume: 1 mL)
IV administration
Dilute to 20 microgram/mL or weaker and give as a continuous infusion. Infuse into a large vein or umbilical artery catheter using a syringe pump with DERS.
RCH Standard Concentrations:
Neonatal:
125 micrograms/25 mL (5 microgram/mL)
All other paediatric ages:
125 micrograms/50 mL (2.5 microgram/mL)
250 micrograms/50 mL (5 microgram/mL)
Other routes of administration
IM: Not recommended.
SC: Not recommended.
Compatible IV fluids
Glucose 5%
Sodium chloride 0.9%
Y-site only and alprostadil 15 microgram/mL or weaker diluted in glucose 5%:
Glucose 5% and sodium chloride 0.45%
Glucose 10%
Potassium chloride 20 mmol/L
Additional information
Extravasation risk.
Never bolus or flush the line where alprostadil is running.
Use a dedicated line with good patency for optimal delivery.
A second point of intravenous access should be immediately available in case of loss of access at short notice.
Use only when facilities for cardio-respiratory monitoring and cardio-respiratory resuscitation exist.
When diluting alprostadil, draw up diluent first as undiluted alprostadil may turn hazy when in contact with plastic. If haziness occurs, discard solution.
Refrigerate, do not freeze.
Contains ethanol.
Concomitant use of CNS depressants (e.g. opioids, parenteral benzodiazepines, IM olanzapine) increase the risk of respiratory depression, sedation, coma and death.