Trade name

Amikacin (Medsurge), Amikacin (SXP), Amikacin (Wockhardt), DBL Amikacin

Presentation and preparation

250 mg/mL (volume: 2 mL)

IV administration

Dilute to 5 mg/mL or weaker and infuse over 30 minutes to 1 hour.

Neonates and infants: Dilute to 5 mg/mL or weaker and infuse over 1 to 2 hours.

Maximum concentration if necessary: 10 mg/mL.

Haemodialysis: Give at the end of haemodialysis.

Other routes of administration

IM: Suitable. Give undiluted.

SC: Not recommended.

Compatible IV fluids

Glucose 5%

Glucose 10%

Sodium chloride 0.9%

Amikacin 5 mg/mL or weaker:

Glucose 5% and sodium chloride 0.9%

Glucose 5% and sodium chloride 0.45%

Hartmann’s

Ringer’s

Y-site only:

Plasma-Lyte 148

Potassium chloride 20 mmol/L

Additional information

Potentially hazardous medication: may require special handling precautions; refer to RCH Safe Handling of Hazardous Medicines Procedure or relevant local guideline.

IV aminoglycoside antibiotics are inactivated by IV cephalosporins, penicillins and teicoplanin; refer to Glossary and Notes. 

Ensure adequate hydration.

Therapeutic Drug Monitoring required; refer to local guidelines.

Solution should be clear and colourless to pale-yellow.

Discard any unused vial contents.